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The mechanism involves shifting melanogenesis from eumelanin (dark pigment) to pheomelanin (lighter pigment) and disrupting the binding between tyrosinase and L-DOPA (Abidin et al., 2025)

Forelimb grip strength was determined by allowing animals to clasp a suspended wire and the time to release was recorded in females [Young ( n = 8), Old Con ( n = 12), and Old mAb ( n = 15)] and males [Young ( n = 8), Old Con ( n = 10), and Old mAb ( n = 9)]

The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas

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