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However, one may argue that even with resting breathing rates, the airflow often contains transitional features like vortices, emerging from the roll-up of shearing fluid layers during flow-structure interactions 46,47,48,49,50,51 at the anatomic bends

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With respect to the substantial similarity criteria, the applicant asserted that SeptiCyte RAPID is not substantially similar to other currently available technologies because SeptiCyte RAPID differs in mechanism, performance, and turnaround time from all current sepsis diagnostic tools by leveraging the host's immune response to systemic inflammation of infectious origin via measurement of the gene expression ratio between upregulated and downregulated genes, and therefore, the technology meets the newness criterion

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Stuerenburg H.J