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Coordination of the cognate metal thus drives transcriptional derepression (an ON switch mediated by allosteric inhibition of DNA operator binding by metal) (Figure 6A, top ), transcriptional corepression (an OFF switch mediated by allosteric activation of DNA binding) of downstream genes (Figure 6A, middle ), or transcriptional activation (an ON switch mediated by metal-dependent conformational changes in the bound DNA, converting a weak promotor to a strong promoter) (Figure 6A, bottom )

In a 2017 study published in the Journal of Molecular Medicine , Hsieh and colleagues reported that BPC-157 promoted angiogenesis in chick chorioallantoic membrane and endothelial tube-formation assays and accelerated blood-flow recovery in a rat hindlimb ischemia model, with the effect attributed to activation of the VEGFR2-Akt-eNOS signaling pathway [1]

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