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Moreover, BPC 157 has been shown to upregulate growth factors like VEGF (vascular endothelial growth factor) that is essential for cellular regeneration and repair

reported strong expression of HIF-1 in the intimal layer of macrophage-like synoviocytes (MLS) in human RA synovium (128), while HIF-2 is mainly expressed in fibroblast-like synoviocytes (FLS) in human RA synovium and collagen-induced arthritis model (CIA) (129)

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