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In a neonatal rat hypoxicischemic brain injury (HIBI) model, hydrogen significantly reduced the Bax/Bcl-2 ratio by up-regulating the expression of the anti-apoptotic protein Bcl-2, while down-regulating the expression of the pro-apoptotic protein Bax and the apoptosis-executing enzyme caspase-3, leading to a reduction in apoptosis (Wang et al., 2020)

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(2019) noticed that women with PCOS who resorted to less consumption of dietary fiber had more HOMA-IR scores, fasting insulin levels, as well as raised triglycerides [122]