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When compared with that in S8/Control mice, the arrangement of germ cells was sparse and disordered and a large number of germ cells were lost in the seminiferous tubules of 8-month S8/ Gss / mice (Fig

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According to the model, the carbonyl group of the N-terminal peptide bond of 23 is coordinated to the Zn 2+ ion, whereas the terminal amine is fixed by three glutamate carboxylates (Glu431, Glu487, and Glu295) ( 27 , it was anticipated that the hydroxyl group of the tyrosine side chain of 25 makes a hydrogen-bond with Glu494 of IRAP, an interaction that is lost in the case of 27 according to the free energy perturbation (FEP) analysis (Jespers et al., 2019), explaining the reduction in binding affinity of compound 27 as compared to the analogous compound 25

The spatial range of tourists is no longer confined to limited tourist attractions of the past, but gradually permeates into the daily lives of local residents, leading to a reconstruction of the urban tourism space