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The animals were kept in the Laboratory Animal Center of Shanghai Jiao Tong University and housed at 2125C, with 4050% humidity, a 12 h light:dark cycle, and free access to drinking water and standard feed

This approach avoids the conversion bottleneck and rapidly replenishes depleted NAD stores

In the animal model, iron chelator Deferiprone (DFP) improves myocardial mitochondrial function, and Liproxstatin-1 (Lip-1), a specific inhibitor of ferroptosis, also protects the integrity of mitochondrial structure (Ravingerov et al., 2020

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