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Serotonin Syndrome risk: With regard to severe nervous system reaction - serotonin syndrome (which includes symptoms such as agitation, hallucination, fast heart rate etc.), this condition is more likely associated with the use of Trazodone than Lunesta

With advancing age and disease duration, MS increasingly shifts toward a phenotype dominated by compartmentalized CNS inflammation, microglial activation, and neurodegeneration, while overt relapses become less frequent ( Table 1 for key immunosenescence features in MS)