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Inversely, Bifidobacteriaceae are decreased in gut microbiota of Nlrp6 -/- mice whereas increased in the fecal microbiome of COPD patients ( In addition, severe COPD was associated with reduced sputum microbiota diversity ( -/- mice could interfere with host defense against lung infection, in particular triggered by Streptococcus pneumonia ( S.p .) and frequently associated with COPD exacerbation ( S.p ( -/- mice ( Statements Data availability statement The original contributions presented in the study are publicly available