For example, BIM-28163, which is a ghrelin analog with full competitive GHS-R1a antagonist characteristics, stops ghrelin-stimulated growth hormone release in rats but stimulates food intake and weight gain
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Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib (Lea et al., 2022
You should also contact your GP if: You are unable to attend scheduled maintenance injections, as missing doses can lead to symptom recurrence You develop new symptoms that might indicate other deficiencies or health problems You are planning pregnancy, as B12 requirements may change You experience persistent side effects such as headaches, dizziness, or gastrointestinal symptoms If you experience any side effects, talk to your doctor, pharmacist or nurse