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Dihexa: the neurotrophic giant from angiotensin IV Origin and structure Dihexa (N-hexanoic-Tyr-Ile-(6) amino-hexanoic-amide, also called PNB-0408) is a modified analogue of angiotensin IV (Ang IV: Val-Tyr-Ile-His-Pro-Phe), developed in Joseph Harding's laboratory (Washington State University) from 2010-2012

Functionally, Dihexa was found to induce spinogenesis and synaptogenesis in hippocampal neurons at picomolar concentrations, indicating its ability to augment synaptic connectivity [2]

Behavioral HealthChoices Program

Based on current evidence, some other Clostridium species (e.g., Clostridium difficile ) may contribute to ADs by disrupting gut microbial homeostasis, secreting exotoxins, or exacerbating intestinal barrier dysfunction