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The safety and efficacy of Citrus aurantium (bitter orange) extracts and p-synephrine: a systematic review and meta-analysis

This chromatin mark facilitates the recruitment of the repressive PER complex, establishing a feedback mechanism that links the positive and negative limbs of the clock (Tamayo et al., 2015)

It stabilizes intestinal permeability and enhances cytoprotection, making it a promising candidate for mitigating NSAID-induced gastroenteropathy and leaky gut syndrome

A multi-center phase-II clinical trial, started a few years ago to investigate the biological and clinical effects of rapamycin in people with ALS, is currently underway and will provide important information for further potential trials [312], thus opening new therapeutic perspectives for ALS