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Ferroptosis-inducing drugs used for tumor treatment Inhibition of the System XC- activity The main function of System X C - is to transfer glutamate from inside the cell to the outside and transfer the extracellular cystine into the cell, and the transferred cystine is used for the synthesis of glutathione in the cell

[DOI] [PMC free article] [PubMed] [Google Scholar] Wang Z

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Human trials must account for variables such as sex-specific pharmacokinetics, age-related renal decline, and gut microbiota diversity, which modulate therapeutic response