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Methylcobalamin, a form of B12, is particularly essential for synthesizing neuronal lipids, regenerating axonal nerves, and exerting neuroprotective effects, potentially improving conditions such as Alzheimer's disease, Parkinsonism, and dementia, while also serving as an approved treatment for peripheral neuropathy

Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

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Metabolic-dysfunction and obesity-pathway preclinical investigations