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Screening tests and accelerated stability tests were performed according to ICH guidelines Q1A (R2)

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The active compounds (gingerols and shogaols) work on the same serotonin receptors that prescription anti-nausea medications target

Approximately one year later, he experienced a severe worsening of his previously very mild neuropathy, and lab evaluation yielded a serum B12 of 220 pmol/l (which is normal, remember!?), but an elevated serum MMA of 1300 nmol/l, supporting the existence of true B12 deficiency