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Keywords GHK peptide, fibroblasts, myofibroblasts, senescence, fibrosis, idiopathic pulmonary fibrosis The loss of cellular homeostasis in fibrosis is characterized by the accumulation of activated fibroblasts, known as myofibroblasts [1], which are responsible for excessive extracellular matrix deposition and tissue remodeling

First strand cDNA was synthesized using random hexamer primer and M-MuLV Reverse Transcriptase

PAGln was identified through untargeted metabolomic analysis in a large-scale clinical study to be increased in circulation and associated with CV-related disease and major adverse cardiovascular events (i.e., stroke, myocardial infarction, and death) 11

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