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Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies

They can be secondary to a reduced MTHFR activity ( 38 mol/L, according to Graham et al, 1997)

Analysis on datasets from Cancer Genome Atlas (TCGA) of the expression of LDLR and HMGCR in ovarian cancer patients, as well as a retrospective study on 65 patients found that patients with a high expression of LDLR and low expression of HMGCR in their tumors, had a poorer disease-free survival, as well as a poorer overall survival, compared to patients with a low LDLR expression [115]

Statistical comparisons of two groups were determined using the two-tailed Student's t-test (InStat v.3.05 and Prism 5)