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2.4 Viral-induced release of mitochondrial DAMPs and innate immune activation Mitochondrial damage during viral infection often leads to the release of mitochondrial damage-associated molecular patterns (DAMPs), such as mtDNA and cytochrome c, into the cytoplasm or extracellular milieu

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Once the ubiquitinated cargo is recognized, it is sequestered into endosomal microdomains by the ESCRT-I and ESCRT-II complexes (25)

Mild fluid retention and temporary joint stiffness may also occur as growth hormone levels begin to elevate