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363,383 The structure of pneumococcal CstR reveals that the two Cys found on opposite subunits within the dimer unit are characterized by long intersubunit S-S distances (79 ), mediated in part by a wedge residue N55, which defines a x-C- N -C W-X-Y-Z motif (Figure 12E)

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In conclusion, probiotics promote the activation of immune cells in the host gastric mucosa, increase the secretion of cytokines such as IL-10 and IgA, and enhance the host immune defense function