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Immunohistochemical analysis of Iba-1 and GFAP showed that the number of activated astrocytes and microglia increased in both the striatum and substantia nigra after MPTP injection, and treatment with our formulation markedly alleviated MPTP-induced glial cell activation

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Notably, ferroptosis inhibitors or proteasome inhibitors can effectively alleviate HSV-1-associated encephalitis by inhibiting NRF2 degradation (Xu et al., 2023)

The human clinical trial data is thinner