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All research must be conducted under appropriate ethical oversight and regulatory compliance with institutional review board approval where applicable

One study found lower vitamin B 12 levels in the cerebrospinal fluid of patients with Alzheimer's disease than in patients with other types of dementia, though blood levels of vitamin B 12 did not differ (65)

Although there is a relationship between low vitamin B12 levels and cognitive decline, clinical studiesincluding those involving people with Alzheimers diseasehave not shown improvement in cognitive function, even doses of the vitamin as high as 1000 micrograms, says Dr