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The most commonly reported side effects are mild and transient: injection site redness or minor bruising, transient fatigue in the first one to two weeks, and occasionally mild headache following the first few injections, a pattern sometimes attributed to the acute shift in cellular energy metabolism as AMPK pathways are upregulated [3]

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This activates protein kinase A, which then activates hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids that can be burned for energy

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