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RM-718 is currently in Phase I for obesity and hypothalamic obesity indications, 43

doi: 10.1074/jbc.M500526200 13 AlimICaulfieldJTChenYSwarupVGeschwindDHIvanovaEet al

Quinlan et al., 2013), complex I and complex III (Venditti et al., 2013) have been shown to be the most important sources of mitochondrial superoxide generation, although significant production of ROS in complex II has recently also been reported ( FIGURE 2 The primary ROS produced by the ETC is superoxide, a free radical with moderate reactivity, whose generation can lead to more reactive or secondary ROS derivatives

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