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According to the New Frontier Data Consumer Survey, between 2017 and 2020 past-month cannabis consumption dropped by 8% among younger Gen Zers (ages 18-20), but increased by 11% for older ones (ages 21-25)

The United States is the primary demand driver, fueled by a large and growing installed base of vaping and nicotine pouch users, an active pharmaceutical NRT market valued in the hundreds of millions annually, and robust academic and commercial research activity around nicotine's therapeutic applications

Although research is limited, some studies have compared the effects of nicotine-free e-cigarettes and those that contain nicotine