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Cyanocobalamin, vitamin B12 preparations containing benzyl alcohol should be avoided in premature neonates because benzyl alcohol has been associated with gasping syndrome, a potentially fatal condition characterized by metabolic acidosis and CNS, respiratory, circulatory, and renal dysfunction

Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies

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