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Aging and OA synergistically affect the mechanical properties of ligaments, reducing tensile strength and altering viscoelasticity, thereby impairing joint proprioception and load distribution

Samples were evaluated in a double-blinded manner

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Effective treatment begins with early nonpharmacologic measures such as physiotherapy, occupational therapy, and psychological support, followed by cautious introduction of pharmacologic options such as gabapentinoids, SNRIs, TCAs, and NAC based on patient response and tolerance level