An open-label non-crossover study of patients with active malignant tumors taking letrozole or TAM (n = 10 per group) found that the results of HPLC-CAD (high-performance liquid chromatography with aerosol detector) of patients who took oral fucoidan in the form of fucoidan extract for 3 weeks (500 mg twice daily) showed no significant difference in letrozole, TAM concentration, and the steady-state plasma concentration of TAM metabolites and no adverse effects of fucoidan
Common vehicles in rodent studies include flavored syrups (strawberry, banana), polyethylene glycol (PEG 400), and dilute ethanol solutions
Along the same line, depleting endogenous GSH with BSO had a worsening effect in some of the models above, including chemically induced pulmonary edema, 21 cigarette smoke, 31 carrageenan-induced pleurisy, 32 and endotoxin-induced pulmonary inflammation
The most common complication is injury to the bile ducts, which can cause infection