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These compounds primarily reduced sciatic pain by understanding several cellular pathways, including those that suppress apoptosis, activate glial cells, and inhibit inflammatory cytokines (TNF-, IL-6, and IL-1) and chemokines (CX3CR1) [] Ferulic acid By preventing neuroinflammation, encouraging sciatic nerve regeneration, and providing analgesia through the TLR4/NF-B pathway, ferulic acid can reduce sciatica