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Transcriptomic analyses of laser capture microdissected neurons from postmortem human AD revealed that NFT-containing neurons expressed signaling pathways consistent with cellular senescence, including SCAPs, upreguled pro-survival and inflammatory pathways and downregulated cell death pathways (35)

PMCID: PMC10925889 Gilron I, DeBow C, Elkerdawy H, Khan JS, Salomons TV, Duggan S, Tu D, Holden RR, Milev R, Buckley DN, Moulin DE (2024) PRECISE trial (Pain relief combination intervention StratEgies): protocol for the clinical trial of a pregabalin-melatonin combination for fibromyalgia