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Another binding protein with ligand-independent activity is IGFBP-4, which physically interacts with Frz8, a Wnt receptor, in cardiomyocytes and inhibits activation by Wnt3A ligand [77]

Studies have also demonstrated that renal cortical structure damage induced by limb ischemia-reperfusion injury can be ameliorated by ALA [80] and ALA, and when combined with the xanthine oxidase inhibitor febuxostat, shows superior protective effects on renal ischemia reperfusion injury [81]

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This study measured and evaluated the liver fibrosis indicators and grades of the two groups