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The PDEVs mixture of grape, red orange, papaya, pomegranate and tangerine activates the Nrf2 pathway by delivering miRNAs, enhancing the antioxidant capacity of endometrial cells ( By inhibiting the inflammatory pathway such as NF-B, PDEVs can downregulate the expression of inflammatory factors such as TNF-, IL-1 and IL-6, and improve the imbalance of reproductive microenvironment caused by inflammatory diseases (such as pelvic inflammatory disease and endometriosis) or oxidative stress (Iriawati et al., 2024)
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PLoS One 12 (8), e0182921
1) Mechanistic gaps in cellcell crosstalk and non-classical regulatory pathways: Current research focuses on ferroptosis in individual immune cell types (T cells, neutrophils, B cells, and macrophages) but lacks insights into the intercellular crosstalk that amplifies ferroptosis-driven autoimmunity and renal injury in LN
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