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However, these approaches do not directly target the underlying molecular mechanisms of injury, nor do they reliably prevent progression to CKD or end-stage renal disease (ESRD) (Gaut and Liapis 2021

Caffeine While moderate caffeine consumption may have some health benefits, excessive intake can reduce glutathione levels

Teams are working on conjugating LR3 to muscle-specific ligands (integrins, dystroglycan) or neuronal ones (cell-penetrating peptides, blood-brain barrier targeting via transferrin receptor transcytosis) to concentrate trophic action where desired while limiting potentially deleterious systemic effects (hypoglycemia, uncontrolled mitogenesis)

[PubMed] Dringen R