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In general conclusions, in population samples with relatively low risk of CVD, SUA is a very weak predictor of CVD, but it is a significant independent predictor among subjects at high or very high risk (30)

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Because heterosynaptic plasticity might play a central role in balancing synaptic changes, we point to evidence for heterosynaptic changes even when considering results of studies aimed at investigation of homosynaptic plasticity (see Box 1 for definitions and discussion)