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For example, the efficacy of several small molecular targets has been well demonstrated in animal models, such as mGluR5 inhibitors, OT, Memantine, and mTOR inhibitors, but is still unsatisfactory in clinical trials

Moreover, B-12 injections improve metabolism, mood, and memory, addressing symptoms like weight gain, mood disorders, and cognitive decline

While human clinical trials remain limited, the consistency of positive results across different injury types and animal species has generated significant interest in the biohacking and athletic communities

Iron supplementation should be guided by laboratory testing (ferritin, complete blood count) rather than empiric use