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This peptide inhibited TGF-1/Smad2/3 and STAT3 pathways, leading to decreased inflammation, tubular atrophy, myofibroblast activation, and fibrotic gene expression (Gwon et al., 2021)

HE staining revealed that the Snakebite Capsules-treated group exhibited well-preserved skeletal muscle morphology with properly aligned muscle fibers and significantly reduced inflammatory cell infiltration, however, co-administration with the ferroptosis inducer Erastin completely abolished the protective effects of Snakebite Capsules, resulting in exacerbated myofiber fragmentation and increased inflammatory infiltration