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Some early insomnia studies found modest improvements in sleep efficiency and sleep latency, while others showed limited or inconsistent benefits

For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig