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Smoking is linked to nearly all measure of socio-economic disadvantage

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Though more than 70 percent of Canadians who purchase cannabis now do so through legal sources, organized criminal groups are heavily involved in the remaining illegal cannabis market, from production to distribution. Marijuanawhich was legalized nationally in Canada in 2018 but remains federally prohibited in the U.S.is not completely without harms to consumers, however, with the study finding that it also scored relatively high for mental harms to users (dependence, withdrawal, short- and long-term impairment of mental functioning), ranking third in that combined category. When it comes to alcohol, which is federally legal in the U.S., it ranked first in 9 of the 16 harm categories: drug-related damage to physical health, withdrawal, short-term impairment of mental functioning, long-term impairment of mental functioning, loss of tangibles, loss of relationships, injury, family and social adversity, and economic cost, the study found

There appears to be a delicate balance between the mitochondrial quality control processes in the physiological state