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Hepatic Antioxidant System The pivotal involvement of the liver in cleansing blood from the gut (considered to be the richest source of oxidants and toxins in the body), it's central role in intermediary metabolism and detoxification processes, its large active Kupffer cell (macrophage) population, imposes high risk for exposure to injurious substances, infectious agents, toxic adducts, and oxidizing substrates

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Scientists approach the study of carbolines in coffee cautiously, due to their strong biological actions on the nervous system and coffee being a rich dietary source

Abstracts Bhutani MS, Ejaz S, Cazacu IM, Singh BS, Shafi M, Stroehlein JR, Mehran RJ, Walsh G, Vaporciyan A Swisher SG , Hofstetter WL