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4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)

Rotation breaks are standard practitioner practice not based on clinical data, but align with the general principle of avoiding continuous peptide exposure

Brain microvascular pericytes in vascular cognitive impairment and dementia

The application of cannabinoids may help since they directly act on astrocytes to diminish cytokine release (Sheng et al., 2005