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Initially this was done to try and gain some information on the possible mode of action of a variety of sulfur containing compounds (chondroitin sulfate, glucosamine sulfate, and others, ) used as dietary supplements to treat diseases of the joints

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In subsequent steps, the activation of pro-caspase 1 results in the formation of active caspase 1, which in turn degrades pro-IL-1 and pro-IL-18 into their mature and dynamic forms