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In the case of TRAPP-pocket, numerical descriptors related to the physicochemical properties of the active site were calculated for each frame of the trajectory (Figure 4) in order to identify energetically high conformations, so these conformations were assumed to be energetically unfavorable (Supplementary Figures S7792

Tricyclic antidepressants including imipramine and amitriptyline are a mainstay of treatment for a variety of chronic pain states, although not FDA-approved for this indication (Tauben & Stacey, 2021)

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It also reduces oxidative stress that causes tanning and hyperpigmentation and promotes free radicals to shield the skin from further damage