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doi: 10.1016/j.pharmthera.2024.108684 68 SutcigilLOktenliCMusabakUBozkurtACanseverAUzunOet al

Further studies employing an ex-vivo skin model supported these findings, suggesting a notable increase in collagen IV synthesis at the dermal-epidermal junction when exposed to the optimized GHK-Cu and LMW HA mixture

an inhibitor of IGF-I action ( Figure 2 )

As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on