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A number of recombinant strategies have been developed to synthesize bispecific antibodies (BsAbs), which include single chain variable fragment (scFv)-derived formats such as diabodies, tandem diabodies, BiTEs (bispecific T-cell engager), and DARTs (Dual Affinity Re-Targeting), as well as immunoglo-bulin G (IgG)-based formats such as Triomab, DVD-Ig (Dual Variable Domain antibodies), and two-in-one antibodies 14

This was subsequently shown to be associated with lower levels of heme-artemisinin adducts 21 and reduced fluorescence labelling of proteins using an artemisinin-based activity probe 12

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Buildup of this toxic metabolite causes hepatic injury by binding covalently to the lipid bilayer of hepatocytes