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Studies completed in subjects on statins have yielded inconsistent results with regard to the importance of raising HDL-C partly due to evidence suggesting that statin (fluvastatin) use in low HDL-C subjects decreased coronary artery disease (CAD) with little to no increase in HDL-C levels (725-727)

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Studies have shown that the activation of Wnt signaling in colorectal cancer is associated with the loss of function of the tumor regulator APC and the involvement of Wnt signaling has been reported in a variety of malignancies, including breast and stomach cancer (98,99)

I., Alves, C., & Tarelho, L