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Abstract Arsenic (As), naturally occurring metalloid and a potential hazardous material, is found in low concentrations in the environment and emerges from natural sources and anthropogenic activities

MicroRNAs such as miR-214-3p and miR-15a-3p bind to the 3 untranslated region of GPX4 mRNA and suppress its translation, sensitizing cells to ferroptosis

In hepatobiliary and pancreatic cancer cell lines (MIA PaCa-2), expression of HIF-1-targeted siRNA vectors reduced HIF-1 mRNA (~13% of control) and protein (~41% of control) levels, blocking tumor growth in vitro and in nude-mouse xenografts (214)

First, all experiments were conducted in vitro using immortalized melanocyte cell lines (PIG1 and PIG3V)