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In Wister albino rats weighing approximately 200 g, 600 mg/kg of APAP administration significantly increased ALT, AST, cholesterol, and low-density lipoprotein, which were attenuated to near normal ranges when administrated 50 and 75 mg/kg of Prosopis farcta (Banks & Sol.) J.F.Macbr

they are known as metabolite-driven and metabolic state-driven approaches, respectively 9,10,11,12,13

4.2 Oxidative stress and mitochondrial dysfunction Renal energy metabolism depends heavily on oxidative phosphorylation, and in CKD, mitochondrial dysfunction and oxidative stress form a vicious cycle that exacerbates tissue injury