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Safety: No adverse effects reported in preclinical studies

Instead Grx2, a mitochondrial isoform, exhibits de-glutathionylation activity for peptides and proteins but with a catalytic activity 10-fold lower with respect to Grx1 ( S -glutathionylation can be catalyzed by glutathione- S -transferase P (GSTP)

Not to simply choose one single position and have that be the only position that you're in

the catheters were exteriorized through the dorsal skin and flushed with heparinized saline before and after blood sample collection and filled with heparin-glycerol locking solution (6 mL glycerol, 3 mL saline, 0.5 mL gentamycin (l OOmg/mL), 0.5 mL heparin (10,000 u/mL)) when not sampled for more than 8 hours