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Specifically, TPL may significantly influence the TLR4-NF-B signaling pathway by inhibiting TLR4 expression, reducing the phosphorylation and degradation of IB, and consequently inhibiting the activation of NF-B (p65)

Thus, oxidative stress, which is the result of an imbalance between prooxidants and antioxidants towards the former due to excessive production of free radicals and/or a decrease in the activity of antioxidant defense, underlies the pathogenesis of many diseases and its study in modeling experimental pathology serves as a fundamental basis for clinical research