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Afr J Biotechnol 10:634863 Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A (2003) Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK

Immune function: Glutathione is essential for lymphocyte proliferation, natural killer (NK) cell activity, and optimal T-cell function

doi: 10.1038/288715a0

The development of 5-amino-1MQ also represents a broader proof-of-concept for targeting metabolic intersections as a research strategy