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Injectable vitamin B12, which can treat significant deficiencies, may cause the following common side effects: More serious side effects of vitamin B12 injections can include: irregular heartbeat heart palpitations hives or a skin rash Vitamin B12 can cause very rare but serious allergic reactions, or anaphylaxis

Research community use most often centers on 100 mg per day oral, taken in the morning

The outer skin may be pulled away from the muscle tissue to ensure the needle doesn't pierce the muscle

The vitamin is also essential for DNA synthesis and red blood cell formation, meaning deficiency can have wide-ranging effects beyond the nervous system, including fatigue and cognitive difficulties